Endocrine Abstracts

We are presenting a case report of 82-year-old patient admitted at Cork University Hospital on 3 July 2015 for investigation of complete ptosis and ophthalmoplegia of left eye which had occurred in couple of weeks time. Initially patient was referred to ophthalmology department by his GP and ophthalmologist found left ophthalmopathy with complete ptosis and referred patient to medical for stroke work up. CT Brain showed abnormal mass in pituitary fossa. MRI Pituitary showed mu...

Background: Amiodarone is frequently associated with thyroid dysfunction. Identifying predictors for amiodarone-associated thyroid dysfunction and assessing treatment outcome may aid clinicians in daily practice.Patients and methods: In our retrospective study, we included 303 consecutive patients with amiodarone therapy for cardiac arrhythmias (260 with atrial fibrillation and 43 with ventricular arrhythmias). Thyroid function tests were performed every...

Objective: Our objective in this study was to identify the type of clinical care received by young type 1 diabetic patients who have made the transition from paediatric to adult care, and to assess the metabolic status of the patients. The research aimed to develop a sustainable and coordinated approach to facilitating the transition between diabetes services for adolescents and reveal from the perspective of the adolescents living with type 1 diabetes their experiences surrou...

In Europe more than 50 million adults are diabetic. Of these, 90–95% have type 2 diabetes (T2D). It is also recognized that an even larger population is insulin resistant and it is thought that treatment at this early phase of the metabolic syndrome may prevent the occurrence of overt diabetes and associated pathologies. We are in the process of developing unacylated ghrelin (UAG) analogues as therapeutics for T2D. Towards this goal, we have used a mouse protocol in which...

Introduction: Anti-TSH-receptor binding antibodies can cross the placenta and can stimulate or inhibit the fetal thyroid, causing fetal and neonatal thyroid dysfunction. We test for these antibodies in all pregnant women with a history of thyroid disease using a TSH binding inhibitor immunoglobulin (TBII) assay. Our aims were to audit our management of TBII positive pregnancies and to review pregnancy outcomes.Methods: Serum TBII concentration was measur...

Introduction: Several studies have shown that cortisol and altered HPA axis activity may participate in pathogenesis and severity of coronary artery disease (CAD).Aim: To examine possible interaction between cortisol secretion and HPA axis activity with severity of CAD.Patients and methods: Diurnal cortisol secretion and dexamethasone suppression test (DST) were analyzed in 200 consecutive patients (mean age 59.3±8.6) referred...